INS and Glucose intolerance: In line with the recovered euglycemia and improved glucose intolerance, diabetic mice giving 200 Smad3KO or WT islets and 100 Smad3KO islets, but not 50 Smad3KO or WT islets and 100 Smad3WT islets, showed decreased blood HbA1c level accompanied by increased insulin level (Figure 1 I and J).