Further, we discovered that CHI3L1 nAb treatments (1 and 5 μg/mL) significantly decreased the migration ability of human NSCLC cell lines H1299 and A549 and PDAC cell lines MIA PaCa-2 and PANC-1 cells as well as CRC cell line MC38 induced by rCHI3L1 using transwell migration assay or wound healing assay (Figure 4B-C). The gene discussed is CHI3L1; the disease is colorectal carcinoma.