The profile of tumor infiltrating immune cells was analyzed by FACS and the results revealed that the percentage of immunosuppressive CTLA4+ or PD-1+ on CD8+ T cells and CD4+CD25+Foxp3+ Tregs was significantly reduced in nCHI3L1 Ab treatment group compared to that in the IgG group (Figure 5F). The gene discussed is FOXP3; the disease is neoplasm.