Tumor infiltrating immune cell profile analyses also revealed the reduction of immuno-suppressive CTLA-4+CD8+ cells and CD4+CD25+Foxp3+ Tregs, whereas the percentage of tumor infiltrating cytotoxic CD8+ T cells and the ratio of M1/M2 macrophages increased in nCHI3L1 Ab treatment group (Figure 6H). The gene discussed is CTLA4; the disease is neoplasm.