After transplanting hypoxia-primed AMPKα2-/- BMDMs into the myocardium after MI, we observed that after MI, the mice did not benefit from transplantation within 28 days, and the long-term survival rate did not significantly differ from that of the vehicle-transplanted mice, which was much lower than that in the hypoxia-primed WT BMDM transplantation group (Figure 6H). The gene discussed is PRKAA2; the disease is myocardial infarction.