To construct a clinicopathological score (CP score) system that permit simple and cost-effective classification of ICC in clinical practice, we finally evaluated the clinical application potential of S100P (positive/negative) and KRT17 (positive/negative) in combination with CA19-9 (≥ 100 U/ml / < 100U/ml). This evidence concerns the gene S100P and intrahepatic cholangiocarcinoma.