TP53 and neoplasm: Similarly, according to the mutational status of TP53, MDM2, RAS, and FGFR3, non-hypermutated upper urinary tract urothelial carcinoma (UTUC) was classified into four subtypes showing unique co-alteration/mutually exclusive patterns, and different mutational subtypes have discrete profiles of gene expression, tumor location/histology, and clinical outcome 65.