SSU72 and Hepatic fibrosis: Importantly, it is possible that the aberrantly up-regulated genes were late-response genes to Ssu72 depletion because the majority of the up-regulated genes were indirect ncRNA and ncRNA processing genes in the MEFs, liver fibrosis-related genes in response to the liver defects in hepatocytes, and indirect hormone- and morphogenesis-related genes in ES cells (Figure S5A).