Despite this, PD1 was upregulated on the surface of both CD4 (tumor, 35 ± 17.2 versus normal, 23.6 ± 18) and CD8 memory T cells (tumor, 38.2 ± 13.5 versus normal, 24.6 ± 14.5) in MPM versus normal lung control, which coincided with downregulation in the expression of the degranulation marker CD107a in both CD4 (tumor, 3.6 ± 3 versus normal, 10.9 ± 5) and CD8 memory T cells (tumor, 4 ± 3.2 versus normal, 9.2 ± 4.6) (Figure 2G-H). This evidence concerns the gene PDCD1 and neoplasm.