Moreover, HCC-derived exosomal circUHRF1 is transferred into NK cells, sponging miR-449c-5p to upregulate TIM-3 expression in turn inducing NK cell exhaustion, thereby favoring immunosuppression and resistance to anti-PD1 immunotherapy in HCC, offering a therapeutic target for patients with HCC (Figure 2A)27. The gene discussed is HAVCR2; the disease is hepatocellular carcinoma.