PRDM16 and gastric cancer: Further studies reported that exosomal ciRS-133 is delivered into preadipocytes, where it inhibits miR-133 and activates PR domain containing protein 16 (PRDM16), thus facilitating white adipose browning, aggravating tumor cachexia, and increasing oxygen consumption in GC patients, thereby highlighting the crucial role of exosomal circRNAs in the pathologic process (Figure 2F) 110.