High expression of USP39 was significantly associated with tumor status (with tumor vs. tumor free: OR = 1.851, 95% CI = 1.212–2.840, P = 0.005), advanced pathologic stage (Stage III/IV vs. Stage I/II: OR = 2.047, 95%CI = 1.256–3.377, P = 0.004), advanced T stage (T3/T4 vs. T1/T2 : OR = 1.914, 95%CI = 1.188–3.118, P = 0.008), and higher histologic grade (G3/G4 vs. G1/G2 : OR = 2.148, 95%CI = 1.399–3.324, P <  0.001). The gene discussed is USP39; the disease is neoplasm.