As a result, the top 10 signaling pathways of D. odorifera leaf extract involved in the treatment of hyperlipidemia were the metabolism of cobalamin-associated A, HIF-1 signaling pathway, insulin resistance, regulation of lipolysis in adipocytes, mTOR signaling pathway, apoptosis, VEGF signaling pathway, estrogen signaling pathway, neurotrophin signaling pathway, and Jak-STAT signaling pathway. Here, INS is linked to hyperlipidemia.