These results are similar to those in previous reports that examined some flavonoids from the extract [66] and suggest that the mechanism by which D. odorifera leaf extract ameliorates hyperlipidemia is related to the downregulation of target proteins, such as HMGCR, SCAP, and SREBP-2, and the upregulation of LDLR. This evidence concerns the gene LDLR and hyperlipidemia.