The most recent study by Tang et al. [39] demonstrated that fasting glucose level, 1 h plasma glucose after OGTT, glycosylated hemoglobin, maternal age, pregestational and maximum weight, pregestational BMI, family history of diabetes in first-degree relatives, acanthosis nigricans, and prenatal weight were potential predictors of insulin treatment during pregnancy, confirming previous evidence. Here, INS is linked to acanthosis nigricans.