MTHFD2 and Friedreich ataxia: Our analysis showed that ADH5, SLC25A36, BFSP-1, CASP1, HSPA1A, PYCARD, SHOX2, LDHB, UQCRB, DNAJC19, MRPL1, MTHFD2, NDUFA5, SCP2, TYMS, MAPK9, and PARG were dysregulated in either FRDA-children or FRDA-adults or both and additionally dysregulated in at least one of the seven NDDs (Table 2).