SOD1 and amyotrophic lateral sclerosis: As for ALS, even though the most common genetic cause of the disease is the expansion of the hexanucleotide intronic repeat GGGGCC in the C9orf72 gene (Ghasemi and Brown, 2018), mutations in the NEM gene SOD1 are considered to be the second most frequent cause of ALS (Bernard et al., 2020).