SYNE1 and Fatigable weakness: A defect in nesprin-1 encoded by the SYNE1 gene can cause Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by joint contracture, myasthenia, and cardiac abnormalities (Zhang et al., 2007; Pillers and Von Bergen 2016; Chen et al., 2017; Heller et al., 2020).