In addition, ApoE-/- activated 5 pathways (apelin muscle, PKCθ in T cell, notch, angiopoietin signaling and NFAT regulation) in Ly6Chigh MC, and 5 pathways (integrin, interferon, crosstalk between DC and NK cells, colorectal cancer metastasis and ephrin receptor) in ly6Clow MC, which may be responsible for subsequent function changes. Here, APLN is linked to colorectal cancer.