PRRT2 and colorectal cancer: In addition, ApoE-/- activated 5 pathways (apelin muscle, PKCθ in T cell, notch, angiopoietin signaling and NFAT regulation) in Ly6Chigh MC, and 5 pathways (integrin, interferon, crosstalk between DC and NK cells, colorectal cancer metastasis and ephrin receptor) in ly6Clow MC, which may be responsible for subsequent function changes.