Similar to PDPN, overexpression of ERM proteins has been detected in various types of cancers: ezrin overexpression in breast, hepatocellular, colon, ovarian, and pancreatic cancers (137–141); radixin overexpression in pancreatic cancer with lymph node metastasis (142); moesin overexpression in skin cancer, colorectal carcinoma, endometrial adenocarcinoma, and glioma (143–146). Here, PDPN is linked to familial pancreatic carcinoma.