In the preoperative setting, the pCR rate to pembrolizumab in the PURE-01 study was high in TMB-high and PD-L1-high (PD-L1 >10%; tumor plus immune cells combined) tumors (6), whereas no significant associations were found for TMB-high and PD-L1-high (PD-L1 >5% of immune cells) subgroups in anti-PD-L1 treated patients in ABACUS (7). This evidence concerns the gene CD274 and neoplasm.