HAVCR2 and neoplasm: In untreated tumors, we observed considerable TIM-3 expression (example image in Figure 3A) on tumor-infiltrating lymphocytes (15% median positivity, range 5%-30%, Supplementary Figure 3A) in most central tumors, as well as in lymph nodal T-cell zones in rare cases having perivesical lymph nodes adjacent to the central tumor (Supplementary Figure 3B).