SMPD1 and COVID-19: Interestingly, there is no association of ASM activity with values of troponin I in patients as a surrogate for damage of myocardial tissue (p=0.3365), thus the serum abundant ASM activity in COVID-19 is proposed to be released from epithelial tissue of the affected lungs as previously described in asthma (96, 97) and acute respiratory syncytial virus bronchiolitis (98).