Granuloma formation plays a major role in mycobacterial pathology, and it has also been observed that mycobacteria exploit TLR-2 signaling for facilitating granuloma formation and in the activation of peroxisome proliferator-activated receptor, which regulates lipid droplet accumulation inside macrophages together aiding in its survival in the host (9). This evidence concerns the gene TLR2 and Granuloma.