MKI67 and neoplasm: For individuals with regional NENs, we still found that patients with ulcerative lesions were prone to neoplasms of a larger size (P=0.002), higher grade (P=0.003), and poorer histological differentiation (P=0.008) with a higher Ki-67 index (P=0.02) and deeper layers of intestinal wall invasion (P=0.03) than patients with protruding lesions.