Statistical analysis showed that there were no significant discrepancies between the groups in terms of the distribution of sex (P= 0.97), age (P=0.15), BMI (P=0.29), family history of cancer (P=0.45), smoking (P=0.22), alcohol consumption (P=0.93), location (P=0.67), positive rates of synaptophysin (P>0.99), chromogranin (P=0.53) and CD 56 (P=0.27), regional lymph node status (P=0.73), distant metastasis (P=0.18), TNM stage (P=0.40), EMVI (P=0.11), PNI (P=0.67), and intervention by surgery (P=0.08), chemotherapy (P=0.42), or radiotherapy (P=0.15). Here, SYP is linked to cancer.