Through the results of oral glucose tolerance tests (OGTTs), peritoneal insulin tolerance tests (IPITTs), IR index (HOMA-IR) and serum insulin tests, they found that intravenous injection of sEVs from MSCs (hucMSC-sEVs) can effectively alleviate hyperglycemia in T2DM rats. This evidence concerns the gene INS and Hyperglycemia.