The results here promote further investigation into whether downstream signaling cascades, such as plasticity in the ARH-POMC→PVH pathway, contributes to the prolonged anorexigenic effects of FGF1, and how the kinetics of FGF1 actions differ in the ob/ob and db/db models of hyperglycemia used in previous studies. The gene discussed is LDLRAP1; the disease is Hyperglycemia.