To address whether changes in neuronal activity are due to synaptic damage in CRS-induced depression-like behaviors, Western blotting and qPCR assays were used to measure the levels of NMDARs (GluN1, GluN2A and GluN2B) and AMPARs (GluA1, GluA2, GluA3 and GluA4) in dHIP and vHIP. This evidence concerns the gene GRIN2B and depressive disorder.