It was found that the mRNA levels of IEGs, such as Arc and Egr, showed obvious decrease in the vHIP after CRS exposure, and the expression levels of glutamate receptors, such as GluA1, GluN2A and GluN2B, as well as the scaffolding protein PSD-95, were also decreased. This evidence concerns the gene DLG4 and congenital rubella syndrome.