Previous studies have shown that in the development process of liver fibrosis, LPS can indirectly or directly stimulate the activation of HSCs and induce the expressions of ECM components, which may involve TLR4/NF-κB, autophagy and other signaling pathways (Soares et al., 2010; Chen et al., 2017). The gene discussed is TLR4; the disease is Hepatic fibrosis.