Pharmacological blockade using A438079 (10 μM) and AZD9056 (10 μM) or transfecting CRC cell lines with P2X7R siRNA reduced CRC proliferation by inhibiting P13/Akt/GSK-3-β/β-catenin pathway which is an important signaling pathway in tumor development (Zhang et al., 2021). Here, AKT1 is linked to colorectal carcinoma.