The Atf4, E2f2, Akt1, and Trp53 genes are all related to cancer, as discussed above, and the Jun gene is closely related to systemic lupus erythematosus (SLE) since some studies suggest that Jun may be involved in the pathogenesis of SLE (Pu et al., 2015). This evidence concerns the gene ATF4 and systemic lupus erythematosus.