Among them, a mutation in Akt1 in human breast cancer and gastric cancer has been found by researchers, and the mutation can stimulate this kinase by enhancing its membrane connection, thus directly correlating Akt1 with the occurrence of cancer (Xu et al., 2018b; Zhang et al., 2019; Yehia and Eng, 2020). Here, AKT1 is linked to breast carcinoma.