CASP3 and acute respiratory distress syndrome: Furthermore, we found that fluorofenidone could significantly increase the expression levels of the mitochondrial anti-apoptosis factor B-cell lymphoma 2 (Bcl-2), decrease the pro-apoptosis factor Bcl-2 X-associated protein (Bax), the ratio of Bax to Bcl-2, and cleaved caspase-3 in the lung tissue of ALI mice (Figures 3C–G), which suggests that fluorofenidone could ameliorate the mitochondrial-mediated apoptosis in LPS-induced ALI mice.