In the PD model induced by 6-OHDA, the level of ERp57 protein in the striatum was increased (Aureli et al., 2014), which can prevent the misfolding and aggregation of α-synuclein, control the quality of protein processing, maintain Ca2+ homeostasis and regulate cellular stress responses (Grillo et al., 2006). The gene discussed is SNCA; the disease is Parkinson disease.