MAPT and Alzheimer disease: To further investigate how ferroptosis could affect glia cells in AD, we looked at the difference in expression of ferroptosis-related genes in microglia between control and AD brains containing only amyloid-β plaques in the occipital cortex (OC) and both amyloid-β and tau pathology in the occipitotemporal cortex (OTC) (Gerrits et al., 2021).