For instance, genes which are important for ferroptosis resistance [e.g., ACSL3, ferritin heavy chain (FTH1), GPX4, GSS and voltage-dependent anion channel 2 and 3 (VDAC2/3)] are downregulated in an early stage of AD pathology but upregulated at later AD stage. This evidence concerns the gene ACSL3 and Alzheimer disease.