MAPT and Alzheimer disease: Studies using in vitro and in vivo models of AD have shown that targeting oxidative stress has a positive effect on neural degeneration, inflammation, Aβ1-42 aggregation, p-tau formation, GSH levels, iron overload, mitochondrial function, motor dysfunction and learning and memory (Fu et al., 2006; Sripetchwandee et al., 2016; Hambright et al., 2017; Zhang et al., 2017; Cong et al., 2019; Ates et al., 2020).