Nrf2 upregulation increased heme oxygenase-1 (HMOX1) levels and decreased AD hallmarks, hippocampal inflammation, oxidative stress, and Aβ-induced memory deficits in AD mouse models (Dumont et al., 2009; Kanninen et al., 2009; Kim et al., 2013; Lipton et al., 2016; Nassireslami et al., 2016; Wang et al., 2016; Fragoulis et al., 2017). This evidence concerns the gene NFE2L2 and Alzheimer disease.