In addition to increased anxiety and impaired extinction memory consolidation, rats show increased negative hypothalamic–pituitary–adrenal (HPA) feedback (Knox et al., 2012a,2016; Han et al., 2014; Liu et al., 2016; Noble et al., 2017; Deslauriers et al., 2018) and altered glucocorticoid receptor expression 7 days after SPS exposure (Liberzon et al., 1999; Wang et al., 2009; Knox et al., 2012b; George et al., 2013). The gene discussed is NR3C1; the disease is Anxiety.