Arguably one of the most complex signalling networks, not only for the number of family members, but also for its high degree of cell, stage- and context-specific signalling outcomes, TGFβ plays a central role in vascular homoeostasis, exemplified by inherited diseases like Marfan and Loeys–Dietz syndromes where excessive TGFβ signalling leads to severe vasculopathy [48]. This evidence concerns the gene TGFB1 and hereditary disease.