VEGFA and retinal disorder: The treatment of some retinopathies was, in fact, revolutionised by the approval in 2004 of Macugen (Eyetech Inc.), the first anti-VEGF agent and the first aptamer to be licensed for clinical use, and subsequent anti-VEGF drugs including Lucentis (Genentech), Eylea (Regeneron Pharmaceuticals) and Avastin (Genentech, off label), administered at slightly different dosage regimens (once a month, on average) by intra-vitreal (IVT) injection.