In a phase I study by Lee et al. at the Pediatric Oncology Branch of the National Cancer Institute (NCI) at the Clinical Center of the US National Institutes of Health on 20 children and young adults with relapsed/refractory B-ALL a CR of 70% was achieved with the TCR ζ (zeta)/CD28 CAR T [ClinicalTrials.gov, number NCT01593696] [46]. The gene discussed is CD28; the disease is precursor B-cell acute lymphoblastic leukemia.