Hay et al. in 2017 in a clinical report of a large cohort of 133 adult patients with CD19 + relapsed/refractory B-ALL, CLL, or NHL reported CRS developed in 70% of patients 62.5% with grade 1 to 3 CRS (grade 1, 26%; grade 2, 32%; grade 3, 4.5%), 3.8% with grade 4, and 3.8% with grade 5. The gene discussed is CD19; the disease is precursor B-cell acute lymphoblastic leukemia.