For example, activity changes in oncogenic pathways often modulate the tumor microenvironment44,45, and we observed a strong correlation between promoter or enhancer methylation and target gene expression for the MAPK pathway (EGFR) and WNT-beta-catenin pathways (CTNNB1, WNT3A and WNT7B) (Fig. 5c). Here, CTNNB1 is linked to neoplasm.