Consistently, gAcrp downregulated SREBP-1 mRNA expression (Fig. 3C and D) and also decreased the binding of SREBP-1 in nuclear extract to a specific dsDNA sequence containing the SREBP-1 response element (SRE) (Fig. 3E and F), clearly indicating that adiponectin suppressed the transcriptional activity of SREBP-1 in breast cancer cells. This evidence concerns the gene ADIPOQ and breast carcinoma.