In addition, co-treatment with EX527 markedly reduced the proportion of cleaved caspase-3 positive cells (Fig. 7E) and Bax expression, but enhanced Bcl2 levels (Fig. 7F) in gAcrp-treated tumors, indicating that inhibition of SIRT-1 prevented tumor cells from apoptosis by adiponectin. This evidence concerns the gene CASP3 and neoplasm.