SIRT1 and cancer: To validate the modulatory effects of adiponectin on cellular fatty acid metabolism and the role of SIRT-1 signaling in its metabolic and anti-cancer actions under in vivo conditions, an orthotopic breast tumor model was established in BALB/c nude mice and the mice bearing breast tumors were treated with gAcrp and/or a pharmacological inhibitor of SIRT-1 (EX527).