FASN and breast cancer: For example, genes involved in fatty acid synthesis (FAS) pathway, including sterol regulatory element-binding protein 1 (SREBP-1), fatty acid synthase (FASN), acetyl-coA carboxylase 1 (ACC1), and ATP citrate lyase (ACLY), have been reported to be overexpressed in breast tumor tissues and are essential for the survival of breast cancer cells [12–15].