SIRT1 and breast carcinoma: It is also notable that blockage of SIRT-1 prevented lipid depletion (Fig. 5F), lipid raft disruption (Fig. 5G), and lipophagy activation (Fig. 5H) by gAcrp, further confirming that SIRT-1 drives lipid metabolic reprogramming in adiponectin-stimulated breast cancer cells.