Unexpectedly, one unanticipated finding was that the mRNA levels of NF-κB, IL-12, IFN-γ, IL-1β and the ratio of IFN-γ to IL-4 in spleen were up-regulated as well as the level of serum IFN-γ in the 500 SS group. The gene discussed is IL4; the disease is synovial sarcoma.