The relevance and added value of the dual antagonist approach has been demonstrated in graft-versus-host disease (GVHD) in which acazicolcept demonstrated a benefit in a humanized GVHD mouse model by improving survival and preventing T cell activation and expansion as compared to single costimulatory pathway inhibitors like CTLA-4-Ig [31]. Here, CTLA4 is linked to graft versus host disease.