ARHGAP5 and posterior cortical atrophy: In this study, we explored that hsa_circ_0003258 may function as an endogenous miRNA sponge to inhibit the expression of miR-653-5p by binding to miR-653-5p in PCa cells, leading to diminish the repression of miR-653-5p on ARHGAP5 3′-UTR and eventually facilitate cell metastasis.