To understand the mechanism underlying the adverse prognosis of somatic APC/CTNNB1 mutations in MM, we sought to investigate the association between the density of TILs and APC/CTNNB1 somatic mutation status given previous reports between immune exclusion and activation of the Wnt/β catenin pathway across various cancers [9]. The gene discussed is CTNNB1; the disease is Miyoshi myopathy.