ACTH-independent macronodular adrenal hyperplasia (AIMAH, OMIM #615954) is also called primary bilateral macronodular adrenal hyperplasia, and the term AIMAH has been recently suggested to be revised to primary macronodular adrenal hyperplasia (PMAH), which is a rare disorder characterized by bilateral macronodular hyperplasia of the adrenal glands with increased cortisol production. The gene discussed is POMC; the disease is acth-independent macronodular adrenal hyperplasia 2.