To make certain the impact of PIK3CG on the anti-tumor effect of miR-142-3p in HCC progression, we transfected miR-NC, miR-142-3p mimics and miR-142-3p mimics + PIK3CG overexpression plasmids into HCCLM3 cells and then gauged cell proliferation, apoptosis, migration, and invasion and the PI3K/AKT/HIF-1α pathway expression. This evidence concerns the gene HIF1A and neoplasm.