Barrett’s esophagus (BE) was checked in 195 patients who had passed methylation, 125 times higher danger of changing into esophageal adenocarcinoma than in healthy and controlled genes like CDH13, TAC1,NELL1, AKAP12, p16, RUNX3, HPP1, and SST, which individually were initiated to anchorage methylated sites [156]. Here, AKAP12 is linked to esophageal adenocarcinoma.