Compromised FAMIN activity also leads to lower reactive oxygen species (ROS) production, decreased bacterial killing, altered NLRP3 inflammasome activation, and cytokine secretion in macrophages (Cader et al., 2016; Lahiri et al., 2017), and Famin−/− mice develop more severe experimental arthritis and colitis (Kang et al., 2020; Skon-Hegg et al., 2019). Here, LACC1 is linked to arthritic joint disease.