LACC1 and systemic-onset juvenile idiopathic arthritis: Loss of function of FAMIN, in sharp contrast, is linked to autoimmunity and autoinflammation, specifically to Still’s disease (also known as systemic juvenile idiopathic arthritis, sJIA), juvenile idiopathic arthritis (JIA), and early-onset Crohn’s disease (Al-Mayouf et al., 2020; Patel et al., 2014; Rabionet et al., 2019; Wakil et al., 2015; Yasin and Schulert, 2018).