Moreover, we found they were primarily correlated with several cancer-related pathways, such as PI3K-Akt signaling pathway (involved with BCL2, EGFR, NOS3 and TP53 et al.), estrogen signaling pathway (involved with BCL2, EGFR, MMP2, NOS3 et al.)and HIF-1 signaling pathway (involved with EGF, EGFR, IL6 and NOS3 et al.). The gene discussed is AKT1; the disease is cancer.