Regarding small molecules, the multitarget iron chelatorVAR10303 has shown beneficial effects on ALS mice.35 In this context, we describe here the design and synthesisof a small library of fasudil–ferulic/caffeic hybrid compoundsand their characterization as an NRF2 signaling inducer and theirtherapeutic potential, especially for ALS patients with a SOD1 mutation. Here, SOD1 is linked to amyotrophic lateral sclerosis.