C9orf72 and amyotrophic lateral sclerosis: Although this mutation wasthe first to be identified,5 more recently,several pathogenic mutations related to ALS have been found, suchas those in the TDP-43, FUS, and C9ORF72 proteins.6 On the other hand, it has been described that single nucleotidepolymorphisms (SNPs) in the promoter region of NEF2L2, which increasedNRF2 protein expression, were associated with a delayed disease onsetof ALS.