Whether the herein observed systemically elevated concentrations of TNF‐α, IL‐4, IL‐6, and IL‐10 on day 1 following surgery were due to the commonly observed post‐surgery inflammatory host response,21, 22 the anaesthesia,23 or whether the PLX‐PAD treatment influenced the enhanced systemic cytokine response remains speculative when studying an isolated case. The gene discussed is TNF; the disease is peripheral arterial disease.