Similarly, NLRP3 inflammasome is a potent inflammatory signals sensor and involved in the pathogenesis of MS and EAE,44 which can recruit PYD and CARD domain‐containing (ASC), then activates caspase 1, then splices substrates including interleukin‐1β (IL‐1β), interleukin 18 (IL‐18), and Gasdermin D (GSDMD), and even in some situation causes pyroptosis, a newly discovered programmed cell death, which leads to cell perforation and a large amount of pro‐inflammatory cytokines release, thus may exacerbate MS/EAE.45 The gene discussed is GSDMD; the disease is myeloid sarcoma.