Two miRNAs up‐regulated in obesity and sarcopenia, miR‐424‐5p33 and miR‐92a‐3p,93 target Smad7, a strong inhibitor of the TGF‐β pathway, which in turn inhibits SMAD2/3. This evidence concerns the gene TGFB1 and obesity due to melanocortin 4 receptor deficiency.