Through comprehensively investigating a large sample (n of public data = 1818, n of in‐house tissue microarrays = 258), our study demonstrated that BCAT1 was significantly highly expressed in HNSCC at both the mRNA and protein levels in all four subgroups of HNSCC—LSCC, OSCC, PSCC, and USCC. Here, BCAT1 is linked to urethra squamous cell carcinoma.