Previous studies have reported that autophagy mediated by SIRT1 plays a vital role in 2‐methoxyestradiol‐mediated prevention of ischemia/reperfusion injury in alcoholic fatty liver,40 and berberine protects against ischemia/reperfusion injury after orthotopic liver transplantation via activation of Sirt1/FoxO3a‐induced autophagy.41 This evidence concerns the gene FOXO3 and Hepatic steatosis.