Hypomethylation of CpG islands at promoter regions of cyclin‐dependent kinase inhibitor 2A (CDKN2A/B), and proapoptotic genes, have been observed in the offspring of mothers with GDM leading to apoptosis in pancreatic islet cells and eventually leading to T2D in adulthood.135. The gene discussed is CDKN2A; the disease is gestational diabetes.