INS and type 2 diabetes mellitus: For example, treatment with 3‐[5‐(3‐(3‐Fluorophenyl)‐3‐oxopropen‐1‐yl)‐1‐methyl‐1H‐pyrrol‐2‐yl]cf‐N‐hydroxy‐2‐propenamide (MC1568), a selective Class II (IIa) histone deacetylase (HDAC II) inhibitor, improved impairment of insulin secretion associated with T2D in the islets of T2D patients.59