Alterations in the methylation status of CpG islands in integrin subunit beta 3 binding protein (ITGB3BP), AF4/FMR2 family member 3 (AFF3), protein tyrosine phosphatase non‐receptor type 2 (PTPN2), cathepsin H (CTSH), and cytotoxic T‐lymphocyte associated protein 4 (CTLA4) genes in human peripheral blood lymphocytes also increased the risk of T1D.100. This evidence concerns the gene CTLA4 and type 1 diabetes mellitus.