Moreover, individual genes such as MAPK1, MYO18B, HOXC6, and the AMP‐activated protein kinase subunit PRKAB1 with known function in muscles, such as the formation of sarcomeres, displayed differential methylation in men with the family history of T2D compared to men without any family history of T2D.125. This evidence concerns the gene HOXC6 and type 2 diabetes mellitus.