Whole‐genome bisulfite sequencing of human pancreatic islet cells identified 457 genes, including nuclear receptor subfamily 4 group A member 3 (NR4A3), Parkinson disease‐2 (PARK2), phosphotyrosine interaction domain containing 1 (PID1), solute carrier family 2 member 2 (SLC2A2), and suppressor of cytokine signalling 2, that had both DMRs and associated changes in gene expression in T2D.114. The gene discussed is NR4A3; the disease is type 2 diabetes mellitus.