In humans, MLL2 has been shown to interact with menin (MEN‐1), mutations in which are responsible for multiple endocrine neoplasias, to regulate the pancreatic β cell proliferation by downregulating the expression of the cell cycle inhibitors such as CDKN1A, CDKN1B, and CDKN2C.68 This evidence concerns the gene MEN1 and Neoplasm of the endocrine system.