SIRT1 and type 2 diabetes mellitus: In another study, when the DNA methylation profile dataset GSE38291, downloaded from the Gene Expression Omnibus database, was examined for changes in DNA methylation of gene promoters associated with T2D by GO analysis, a total of 38 genes (e.g., SIRT1, N‐acetyltransferase 6 [NAT6], phospholipase A2 group XIIB [PLA2G12B], and nuclear factor of activated T cells calcineurin‐dependent 1 [NFATC1]) were identified to be differentially methylated between the muscles of T2D and control samples.