Alterations in CpG methylation levels in the regulatory regions of many of the genes related to metabolic pathways such as thioredoxin interacting protein (TXNIP),110 solute carrier organic anion transporter family member (SLC30A8),111 GLP1 receptor (GLP1R),112 peroxisome proliferator‐activated receptor gamma (PPARG), potassium voltage‐gated channel subfamily q member 1 (KCNQ1), transcription factor 7‐like 2 (TCF7L2), and insulin receptor 1 (IRS1) have been observed in T2D patients.113. This evidence concerns the gene TXNIP and type 2 diabetes mellitus.