In the 32 PD-L1-evaluable ESCC patients, ORRs were 76.5% and 53.3% for patients with CPS ≥ 10 (n = 17) and CPS < 10 (n = 15), with median DoR being not reached (95% CI: 2.2,-) and 5.0 months (95% CI: 2.2,-), and median PFS being not reached (95% CI: 4.4,-) and 4.7 months (95% CI: 4.1, 9.0), respectively. The gene discussed is CD274; the disease is esophageal squamous cell carcinoma.