A high proportion of TAMs is a poor prognostic marker for many cancers, including melanoma [97] and pancreatic [98] cancers, especially when coupled with reduced numbers of CD8 T cells, due to the lack of cytotoxicity and ability to promote tumor invasion through the production of VEGF to induce angiogenesis and shape the TME [99]. The gene discussed is CD8A; the disease is neoplasm.