SREBPs are essential to maintain Treg viability and immunosuppression in the TME, as SCAP deletion to inhibit the expression of SREBP target genes increased the frequency of IFN-γ+ Tregs in the tumor while also increasing the number of TNF-α- and IFN-γ+ polyfunctional CD8 T cells. The gene discussed is CD8A; the disease is neoplasm.